Job Description

Job Description

Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our robust and complex R&D pipeline requires a focus on efficiency and prioritization as we scale. The Vertex finance function is integral to achieving our company's strategic goals, providing critical insights and analysis in support of decisionmaking across the organization. We are investing in our ability to provide datadriven insights by organizing and automating financial data and processes to enable our growing global scale. We are also leveraging best practices to strengthen our business partnering and decision support capabilities. By joining our function, you will become part of a fastmoving, forwardthinking team to support the ongoing growth of a leader in the biotechnology industry.

General Summary

The Senior Director, Global Development FP&A is a seasoned finance leader who partners directly with our Global Clinical Development (early and latestage programs) organizations and crossfunctional program teams to run global financial planning, forecasting, and strategic analysis. Reporting to the VP of R&D Finance, this highly visible role serves as a strategic advisor to the Chief Medical Officer's organization and senior leadership, influencing portfolio prioritization and investment decisions through financial insights. The ideal candidate brings deep expertise in clinical trial finance, executive presence, and a proven ability to drive business outcomes in a dynamic, sciencedriven environment. This role is for you if you possess strong decision support analytical skills, project management expertise, team management skills, and demonstrated ability to collaborate with crossfunctional teams to drive innovation and deliver successful product development outcomes.

Key Duties and Responsibilities

A key leader in financial planning and analysis within our function, your responsibilities entail:

Advanced Scenario Planning and Risk Analysis:

• Build, maintain, and own clinical programlevel budgets (Phase 1 to Phase 3), clinical trial cost models, and forecasts; produce costtocomplete and cost per patient analysis used in strategic decisions.
• Lead advanced scenario modeling for clinical programs, including sensitivity analyses on timelines, enrollment rates, and regulatory milestones to inform go/nogo decisions.
• Translate clinical development plans into financial implications and ROIbased recommendations.

Strategic Influence and Business Partnership:

• Participate in crossfunctional program teams and governance committees, providing realtime financial guidance.
• Deliver program dashboards, KPIs and trend analyses for executive and portfolio reviews.
• Prepare and present executivelevel updates.

Team Leadership:

• Lead and develop a team of 68 clinical finance professionals: set team priorities, establish processes, and build scalable operating mechanisms for financial support
• Drive automation and digital transformation of clinical finance processes, leveraging tools like Hyperion, Oracle, and emerging analytics platforms to improve accuracy and scalability
• Mentor staff on forecast accuracy, stakeholder management and financial modeling best practices
• Drive a collaborative, serviceoriented culture between finance and Global Clinical Development organizations

Governance and Compliance Leadership:

• Oversee monthend and quarterend close activities related to clinical expense (accruals, reconciliations, GL review).
• Ensure accurate, timely accruals for CROs, FSPs, sites, labs and other clinical vendors. Maintain auditready documentation for clinical program spend
• Improve transparency and accountability around clinical opex and resource allocation through clear processes, benchmarks and metrics

Basic Requirements

• Bachelor's degree in finance, Accounting, or related field; MBA or CPA/CFA strongly preferred.
• 12+ years of progressive FP&A experience, with at least 5 years in the pharmaceutical or biotech industry.
• Experience supporting R&D or Clinical Development functions at a global scale.
• Strong understanding of R&D processes, portfolio management, and project evaluation methodologies.
• Proven ability to manage complex budgets, forecasts, and analyses in a dynamic, fastpaced environment.
• Excellent communication and presentation skills, with the ability to influence stakeholders at all levels and a proven ability to present complex financial insights to senior stakeholders.

Important Knowledge and Skills

• Deep understanding of pharmaceutical industry dynamics and executivelevel business partnering.
• Handson exposure to clinical operations and/or CRO/FSP budgeting.
• Strong analytical capabilities in portfolio analysis.
• Proficiency in Microsoft Office and financial systems, including Hyperion and Oracle.
• Proven ability to lead change in complex, crosscultural matrix environments.
• Exceptional communication and influencing skills across senior leadership and crossfunctional teams.
• Ability to apply broad market knowledge to drive financial performance and strategic outcomes.
• Strategic thinker with attention to detail.

Pay Range

$212,000 - $318,000

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other jobrelated factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive marketleading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a weeklong company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

HybridEligible Or OnSite Eligible

Flex Eligibility Status

In this HybridEligible role, you can choose to be designated as:
1. Hybrid : work remotely up to two days per week; or select
2. OnSite : work five days per week onsite with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and nondiscrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status or any characteristic protected under applicable law. Vertex is an EVerify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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